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THE DUAL PATHWAY

Endothelin-1 (ET-1) and angiotensin II (ANG II) both play fundamental roles in the pathophysiology of kidney diseases such as IgAN1–4

They act in tandem via their receptors ETAR and AT1R to amplify underlying disease damage and compromise the glomerular filtration barrier, leading to a progressive loss of kidney function1–11

The impact of ET-1 and ANG II on pathophysiology and disease progression of IgAN

Endothelin-1 and angiotensin II in IgA nephropathy flow diagram
FSGS

The combined effect of ET-1 and ANG II 
contributes to progression to kidney failure1–4,6–11

Discover the underlying disease 
damage amplified by the dual pathway in IgAN

DISCOVER THE ROLE OF PROTEINURIA IN ACCELERATING KIDNEY DISEASE PROGRESSION

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